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. 2017 Sep 8;7:10995. doi: 10.1038/s41598-017-11316-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Presynaptic mechanisms are not involved in TBI-dependent LTP impairment and CN2097-induced LTP restoration. (A) Paired pulse ratios (PPRs) for vehicle- and CN2097-treated rats in both hemispheres at 1d (top) and 3 d (bottom) after TBI at baseline (BL) and after LTP induction (LTP). (B) Examples of fEPSP traces representing averages of 10 responses at baseline in the contralateral (Contra-Hip, black) and ipsilateral (Ipsi-Hip, red) hippocampi in vehicle- (top) and CN2097-treated (bottom) rats at 3 d following TBI. Results indicate no differences between groups. (C) Interhemisphere ratios (Ipsi/Contra) of PPR results at baseline (left) and after LTP induction (right) for vehicle- (yellow) and CN2097-treated (blue) rats. Neither TBI nor CN2097 treatment modifies PPRs. Data represent mean ± SEM.