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. 2017 Sep 8;7:10995. doi: 10.1038/s41598-017-11316-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Brain regional volume analysis in CN2097- versus vehicle-treated rats. Photomicrographs (A) show coronal brain sections from ipsilateral and contralateral hemispheres from vehicle- and CN2097-treated rats, demonstrating comparable injury profiles. Bar graph (B) shows regional brain volume measurements for vehicle-treated (TBI Vehicle; n = 6) and CN2097-treated (TBI CN2097; n = 8) rats, indicating comparable ipsilateral and contralateral regional brain volumes of the cerebral cortex, hippocampus, and corpus callosum. *Indicates significant (p < 0.01) differences between ipsilateral and contralateral hemispheres for both treatment groups. Data represent mean ± SEM.