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. 2017 Sep 8;7:10949. doi: 10.1038/s41598-017-10224-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Profiling of mRNAs and miRNAs in the spinal cord of cancerous mice. (A) Schematic representation of RNA screening strategy. (B) MA plot representing differential expression of mRNAs in bone-cancer-pain condition compared to control condition: 3909 mRNAs differentially expressed. (C) Heatmap representation of miRNA expression in cancerous versus naive mice: out of 742 miRNAs tested, 525 miRNAs were differentially expressed with 175 up-regulated (fold change > 2) and 350 down-regulated (fold change < 0.5).