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. 2017 Sep 8;7:10972. doi: 10.1038/s41598-017-11592-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of the primarily affected metabolic pathways in the hemolymph of silkworms reared on the artificial diet. The pathways were simplified and organized based on Kyoto Encyclopedia of Genes and Genomes pathways (http://www.kegg.jp/). The data were collected from the metabolomic data of female larvae of the high feed intake strain reared on the artificial diet (HiA females). The font color represents the level of change in the silkworms reared on the artificial diet compared with that of the silkworms of the same strain reared on fresh mulberry leaves (HiM females); red indicates a higher level; blue indicates a lower level; and black indicates no significant change. Black font with a black frame indicates an unidentified metabolite.