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. 2017 Sep 8;7:11028. doi: 10.1038/s41598-017-11403-w

Figure 6.

Figure 6

Different lines grow differently in Matrigel in vitro and differently require macrophages in vivo. (a) Quantification of the indicated cancer cell lines growth in vitro on growth factor reduced matrigel. *P value < 0.05 (two-way ANOVA between the growth of luminal vs basal cells) (b) Bright field images of the indicated cancer cell lines on matrigel. Scale bar: 100 µm. (c) Mass of BT20 transplanted and growth for 7 weeks either with PBS or Clodronate liposomes in growth factor reduced matrigel. *P value < 0.05 (n = 4, two tail T-test) (d) H&E of BT20 tumours in c. Scale bar: 100 µm. (e) H&E of 4T1 transplanted grown for 1 week either with PBS or Clodronate liposomes in growth factor reduced matrigel. Scale bar: 100 µm. (F) H&E of MDAMB231 transplanted grown for 1 week either with PBS or Clodronate liposomes in growth factor reduced matrigel. Scale bar: 100 µm.