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. 2017 Sep 8;7:11000. doi: 10.1038/s41598-017-11374-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MIER3 is down-regulated in paraffin-embedded clinical CRC tissues and is a prognostic factor for poor overall and disease-free survival in CRC patients. (Aa–c) Representative images of MIER3 expression in normal intestinal epithelium and CRC specimens as examined by IHC. Negative staining for MIER3 in a tumor tissue sample and high expression of MIER3 in its normal mucosal counterpart from the same patient were observed in one field (original magnification 200×) or two independent magnification fields (original magnification 400×). (d) Positive expression of MIER3 in colorectal tumor tissue samples (original magnification 400×). (e,f) High expression of MIER3 in normal intestinal epithelial cells and CRC cells (original magnification 400×), (B) Kaplan–Meier survival analysis of (above) overall and (below) disease-free survival duration in all patients according to MIER3 expression. The log-rank test was used to calculate p values.