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. 2017 Sep 8;7:11043. doi: 10.1038/s41598-017-09147-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TFO binding of 15-mer ON sequences: (a) _c-MYCDS45 and electrophoretic mobility shift profile of _c-MYCDS45 in the presence of (b) ON2-5′DNA and (c) ON2. Hybridization with ON in the absence (left side) and in the presence (right side) of BQQ carried out during 24, 48 and 72 h. Triplex structures are detected as slower migrating bands. DNA duplex and triplex complexes are indicated as DS and TS, respectively. LNA is indicated in capital letters and DNA is in small letters. Distribution of glycosidic torsion (χ) and ribose pseudorotation (P): (Panels d and e) ON2-5′DNA (black) and ON1 (red) strands free in solution. (Panels f and g) ON2-5′DNA bound to the _c- _MYCDS19. The sketches of base pair orientation and sugar pucker beside the graphs depict the conformation corresponding to the gray regions in the panel.