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. 2017 Sep 8;7:11023. doi: 10.1038/s41598-017-11262-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HBB2 inhibits tumor incidence and multiplicity in a mouse model of high-risk UV radiation-mediated cutaneous squamous cell carcinoma. Female SKH-1 hairless mice were exposed to UVB radiation (30 mJ/cm²/session) twice a week for 17 weeks, and then distributed into two groups. The mice from each group were treated topically with either 100 μl of 80% acetone (vehicle control group, n = 21) or 1 μmol of HBB2 dissolved in 100 μl of 80% acetone (HBB2-treatment group, n = 18) twice a week, for 12 weeks. Tumor incidence (a) is represented as the percentage of tumor-bearing animals in each group. Tumor multiplicity (b) is expressed as the total number of tumors in each group divided by the number of animals at risk; the data represent mean values ± SEM.