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. 2017 Sep 8;7:10957. doi: 10.1038/s41598-017-11438-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased inflammatory responses upon Mtb infection in male lungs. Cytokine and chemokine levels were measured in lung lysates of female and male C57BL/6 mice on day 21 (A) and 152 (B) after Mtb H37Rv aerosol infection. Data pooled from two independent experiments are shown as mean ± SD (n = 9–10). Statistical analysis was performed by Mann-Whitney test. Correlations between cyto- or chemokines plotted versus bacterial burden in in lungs for day 21 (C) or d152 (D) in males and females. Each dot represents an individual sample (n = 9–10; females gray; males black).