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INa mediated EADs. Typical EADs due to reactivation of INa in the physiologically detailed model. ICaL was blocked (GCaL = 0) to show explicitly these EADs are due to reactivation of INa. (A) EADs are periodic when pacing cycle length (PCL) = 1220 ms. (B) EADs show period 2 when PCL = 613 ms. (C) EADs are irregular when PCL is 470 ms. Irregular EADs shown here are sensitive to the initial conditions (see Fig. 3).
