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. 2017 Sep 4;8:459. doi: 10.3389/fneur.2017.00459

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Copyright © 2017 Murgia, Muroni, Puligheddu, Polizzi, Barberini, Orofino, Solla, Poddighe, Del Carratore, Griffin, Atzori and Marrosu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scores plots obtained from nuclear magnetic resonance spectra of serum samples from controls and patients with epilepsy. (A) Scores plot from the multivariate orthogonal partial least square discriminant analysis model between controls (C): C (●) and patients with epilepsy: P (O): each point represents a single serum spectrum, with the position determined by the contribution of the 159 variables. (B) Validation of the corresponding model by permutation test (n = 500). (C) Scores plot from the multivariate orthogonal partial least square discriminant analysis of a three classes model: healthy subjects (●), responder (R) patients (Δ), and non-responder (NR) patients (). (D) Statistical validation of the corresponding model by permutation test.

Inline graphic — Scores plots obtained from nuclear magnetic resonance spectra of serum samples from controls and patients with epilepsy. (A) Scores plot from the multivariate orthogonal partial least square discriminant analysis model between controls (C): C (●) and patients with epilepsy: P (O): each point represents a single serum spectrum, with the position determined by the contribution of the 159 variables. (B) Validation of the corresponding model by permutation test (n = 500). (C) Scores plot from the multivariate orthogonal partial least square discriminant analysis of a three classes model: healthy subjects (●), responder (R) patients (Δ), and non-responder (NR) patients (). (D) Statistical validation of the corresponding model by permutation test.