Table 4.

Metabolites significant altered among the classes control (C), responder (R), and non-responder (NR).

Metabolites	C mean (mM) ± SD	R mean (mM) ± SD	NR mean (mM) ± SD	p value [Mann–Whitney test (MW) test]: C vs R	p value [Holm–Bonferroni correction (HBonf.C)]: C vs R	p value (MW test): C vs NR	p value (HBonf.C): C vs NR	p value (MW test): R vs NR	p value (HBonf.C): R vs NR
3-OH-butyrate	0.10 ± 0.07	0.12 ± 0.06	0.14 ± 0.1	ns	ns	0.002	0.01	ns	Ns
Acetate	0.061 ± 0.01	0.09 ± 0.02	0.1 ± 0.02	<0.0001	0.001	0.002	0.01	ns	ns
Acetoacetate	0.01 ± 0.01	0.02 ± 0.01	0.03 ± 0.01	0.005	0.025	<0.0001	0.001	0.01	ns
Acetone	0.0008 ± 0.001	0.008 ± 0.008	0.02 ± 0.01	<0.0001	0.001	<0.0001	0.001	ns	ns
Citrate	0.12 ± 0.04	0.10 ± 0.04	0.09 ± 0.02	ns	ns	0.009	0.04	ns	ns
Glucose	2.02 ± 0.05	1.81 ± 0.03	1.74 ± 0.03	ns	ns	0.01	0.04	ns	ns
Lactate	1.88 ± 0.04	1.72 ± 0.05	1.16 ± 0.05	ns	ns	<0.001	0.001	0.001	0.007
Scyllo-inositol	0.16 ± 0.01	0.4 ± 0.5	0.24 ± 0.2	0.04	ns	ns	ns	ns	ns

Summary of the univariate statistical analysis. U-MW was performed, and all the results underwent the HBonf.C.