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. 2017 Sep 4;8:77. doi: 10.3389/fpsyt.2017.00077

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Copyright © 2017 Rahman, Zavitsanou, Purves-Tyson, Harms, Meehan, Schall, Todd, Hodgson, Michie and Weickert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative autoradiographs of regions from maternal immune activation offspring. Coronal sections from adult (postnatal day 63–91) male offspring from vehicle (control: a,c) or polyI:C (b,d) treated dams were processed with tritiated radioligands to detect (A) N-methyl-d-aspartate receptor (NMDAR) channel (MK-801), (B) NR2A (CGP39653), and (C) NR2B (Ifenprodil) binding in (a,b: ~2.50 mm bregma) cortical, striatal, and (c,d: ~−3.10 mm bregma) hippocampal regions. (A) PolyI:C offspring showed significantly increased NMDAR channel binding in (a,b) cingulate and striatum, but not (c,d) hippocampal regions. (B) PolyI:C offspring showed significant increases in NR2A binding overall in all quantified regions. (C) PolyI:C offspring showed no significant change in NR2B binding overall in any quantified region. Scale bars represent 500 µm.