Figure 3.

N-methyl-d-aspartate receptor (NMDAR) channel binding alterations in cortex and striatum from adult offspring exposed to vehicle (control; black) or polyI:C (gray) during early (GD10) or late (GD19) gestation. Tritiated MK-801 binding was used to quantify NMDAR channel levels. Significantly increased NMDAR binding was found in the cingulate subregion of polyI:C offspring compared to controls (A). Male, but not female, polyI:C offspring specifically exhibited significantly increased NMDAR channel binding in the striatum (B). Bars represent mean ± SEM (n = 15–28 rats per group). Cg, cingulate cortex; M1, motor cortex; Aud, auditory cortex (*p < 0.05, ***p < 0.001).