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. 2017 Sep 4;8:77. doi: 10.3389/fpsyt.2017.00077

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Copyright © 2017 Rahman, Zavitsanou, Purves-Tyson, Harms, Meehan, Schall, Todd, Hodgson, Michie and Weickert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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N-methyl-d-aspartate receptor-related mRNA alterations in cortex, hippocampus, and striatum from male adult offspring exposed to vehicle (control; black) or polyI:C (gray) during early (GD10) or late (GD19) gestation. In situ hybridization was used to quantify NR1 mRNA (GRIN1; A,B) and NR2A mRNA (GRIN2A; C,D). Male polyI:C offspring had (A) no change in NR1 mRNA overall in any quantified region, but (C) significantly increased NR2A mRNA in cortex and hippocampus. (B) Male polyI:C offspring had significantly elevated NR1 mRNA in, the striatal subregion, AS. (D) PolyI:C offspring had significantly increased NR2A mRNA, in the hippocampal subregions, DG, and CA1. Bars represent mean ± SEM (n = 25–28 rats per group). DG, dentate gyrus; CA3, cornu ammonis 3; CA1, cornu ammonis 1; DS, dorsal striatum; AC, nucleus accumbens core; AS, nucleus accumbens shell (*p < 0.05, **p < 0.01).