Table 2.

Correlation between the composition of CCR oligomers and the CCL5-mediated changes to glutamate release.

	Human cortical synaptosomes		Mouse cortical synaptosomes		Mouse spinal cord synaptosomes
	Basal glutamate release	12 mM KCl-evoked glutamate overflow	Basal glutamate release	12 mM KCl-evoked glutamate overflow	Basal glutamate release	15 mM KCl-evoked glutamate overflow
CCR1	↑	↓	↑	↓	↑	↑
CCR3	Not involved	↓	Not involved	↓	Not involved	Not involved
CCR5	↑	↓	↑	↓	↑	↑

The table resumes the modulatory action of CCL5 on the release of glutamate (measured as release of preloaded [³H]d-aspartate) correlating these events to the CCR subunits involved in the expression of chemokine oligomers targeted by the chemokine.

↓, inhibition of glutamet relesae; ↑, facilitation of glutamate exocytos.