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. 2017 Sep 6;19(10):830–841. doi: 10.1016/j.neo.2017.08.002

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The relationship between cycle progression and apoptosis induced by combination of SCH900776 and LA-12/cisplatin in HCT116 cells. (A) Percentage of wt and p21^−/− HCT116 cells with caspase-3 cleavage related to the cell cycle progression (propidium iodide, flow cytometry) following their pretreatment (2 hours) with SCH900776 (SCH, 3 μM) and subsequent treatment (48 hours) with LA-12 (0.75 μM) or cisplatin (CDDP, 20 μM). Results are means ± SEM or representative of three independent experiments. Statistical significance: P < .05, * versus control, ‡ versus SCH and Ο versus LA-12 or CDDP.