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Percentage of HCT116 p53−/− cells with caspase-3 cleavage related to the cell cycle progression (propidium iodide, flow cytometry) following their pretreatment (2 hours) with SCH900776 (SCH, 3 μM) and subsequent treatment (48 hours) with LA-12 (0.75 μM) or cisplatin (CDDP, 20 μM). Results are means ± SEM or representative of three independent experiments. Statistical significance: P < .05, * versus control, ‡ versus SCH and Ο versus LA-12 or CDDP.
