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(A, B) Percentage of HCT116 p53−/− cells in individual cell cycle phases (flow cytometry) following their pretreatment (2 hours) with SCH900776 (SCH, 3 μM) and subsequent 48-hour (A) or 72-hour (B) treatment with LA-12 (0.75 μM) or cisplatin (CDDP, 20 μM). Results are means ± SEM of three independent experiments. Statistical significance: P < .05, * versus control, ‡ versus SCH and Ο versus LA-12 or CDDP.
