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The level of γ-H2AX, phosphorylated (Ser296) and total Chk1, cyclin B1, survivin, and phosphorylated (Ser10) histone 3 (p-H3) in HCT116 wt cells (Western blotting) following their pretreatment (2 hours) with SCH900776 (SCH, 3 μM) and subsequent treatment (8 or 24 hours) with LA-12 (0.75 μM) or cisplatin (CDDP, 20 μM). Results are representatives of three independent experiments.
