Supplementary Figure 12.

Percentage of HCT116 wt, p53^−/−, and 21^−/− cells with phosphorylation (Ser10) of histone 3 (p-H3) (flow cytometry) following their pretreatment (2 hours) with SCH900776 (SCH, 3 μM) and subsequent treatment (48 hours) with LA-12 (0.75 μM) or cisplatin (CDDP, 20 μM). Results are means ± SEM of three independent experiments. Statistical significance: P < .05, * versus control, ‡ versus SCH, Ο versus LA-12 or CDDP and Δ for wt versus p53^−/− or wt versus p21^−/−