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Percentage of annexin V+/PI+ HCT116 PTEN+/+ and PTEN−/− cells following pretreatment (2 hours) with SCH900776 (SCH, 3 μM) and subsequent treatment (48 hours) with LA-12 (0.75 μM) or cisplatin (CDDP, 20 μM). Results are means ± SEM or representatives of three independent experiments. Statistical significance: P < .05, * versus control, ‡ versus SCH, Ο versus LA-12 or CDDP and Δ for PTEN+/+ versus PTEN −/− cells.
