Table 5. . Genetic association of the OCT1 polymorphisms with morphine-related respiratory depression and postoperative nausea and vomiting.
| OCT1 SNPs | Genotype (n) |
RD |
Prolonged stay due to RD |
PONV |
Prolonged stay due to PONV |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % | p† | p‡ | p§ | % | p† | p‡ | p§ | % | p† | p‡ | p§ | % | p† | p‡ | p§ | ||
| rs12208357 | C/C (264) | 29 | 0.90 | 0.23 | 0.96 | 9 | 0.69 | 0.43 | 0.56 | 14 | 0.038 | 0.55 | 0.027 | 5 | 0.024 | 0.69 | 0.016 |
| C/T (46) | 27 | 11 | 28 | 15 | |||||||||||||
| |
T/T (1) |
0 |
|
|
|
0 |
|
|
|
0 |
|
|
|
0 |
|
|
|
| rs34130495 | G/G (298) | 29 | 0.14 | 0.35 | 0.16 | 10 | 0.54 | 0.54 | 0.60 | 16 | 0.33 | 0.55 | 0.36 | 6 | 0.81 | 0.82 | 0.77 |
| G/A (12) | 17 | 8 | 8 | 8 | |||||||||||||
| |
A/A (1) |
0 |
|
|
|
0 |
|
|
|
0 |
|
|
|
0 |
|
|
|
| rs72552763 | GAT/GAT (222) | 27 | 0.22 | 0.007 | 0.66 | 10 | 0.33 | 0.31 | 0.40 | 16 | 0.86 | 0.89 | 0.81 | 6 | 0.73 | 0.36 | 0.87 |
| GAT/-(82) | 27 | 9 | 17 | 6 | |||||||||||||
| |
–/–(7) |
71 |
|
|
|
0 |
|
|
|
14 |
|
|
|
0 |
|
|
|
| rs34059508 | G/G (298) | 28 | 0.84 | – | 0.84 | 10 | 0.10 | – | 0.10 | 16 | 0.94 | – | 0.94 | 6 | 0.16 | – | 0.16 |
| G/A (13) | 31 | 0 | 15 | 0 | |||||||||||||
The proportions of ADR cases are shown by genotypes of each of the OCT1 polymorphisms. Genetic associations with RD and PONV were tested by logistic regression adjusting for significant covariables, assuming additive, dominant and recessive genetic effects.
†Additive.
‡Dominant.
§Recessive.
ADR: Adverse drug reaction; PONV: Postoperative nausea and vomiting; RD: Respiratory depression.