Table 1. . Commercially available CYP2D6 genotyping and sequencing tests.
| Assay | Star (*) allele haplotypes interrogated | Company |
|---|---|---|
| xTAG CYP2D6 Kit v3 |
*2, *3, *4, *5, *6, *7, *8, *9, *10, *11, *15, *17, *29, *35, *41, *xN |
Luminex† |
| Ion AmpliSeq Pharmacogenomics Research Panel |
*2, *2A, *3, *4, *5, *6, *7, *8, *9, *10, *11, *12, *14, *15, *17, *20, *29, *35, *41, *29/*70, *xN |
ThermoFisher/ Ion Torrent‡ |
| DMET Plus |
*2, *3, *4, *5, *6, *7, *8, *9, *10, *11, *12, 14A, *14B, *15, *17, *18, *19, *20, *21, *29, *38, *40, *41, *42, *44, *56A, *56B, *64 |
ThermoFisher/ Affymetrix |
| PharmacoScan |
*2, *3, *4, *5, *6, *7, *8, *9, *10, *11, *12, *14A, *14B, *15, *17, *18, *19, *20, *21, *29, *38, *40, *41, *42, *44, *56A, *56B, *64, plus copy number variation |
ThermoFisher/ Affymetrix |
| iPLEX CYP2D6 Panel |
*1, (*2;*28;*32;*55;*59), (*2A;*31;*51), *2D, (*2L;*45B;*46), *2M, *3, *4, *4B, *4J, *4K, *4M, *4N;P, *53,*6, *6C, *7, *8, *9, (*10A;*37;*54), (*10B;*47;*49;*52;*72), *11, *12, *14A, *14B, *15, *17, *18, *19, *20, *21ª, *21B, *27, *29, *30, *34, *35, *36, *38, *39, *40, *41, *42, *44, *45A, *56A, *56B, *57, *58, *63, *64, *65, *68, *69, *70, *71, *82, *83, *84 |
Agena Bioscience |
| iPLEX PGx Pro Panel |
*1A, (*2A;*31;*51), (*2L;*35;*71), *3, *4, *4M, *6, *7, *8, *9, (*10;*36;*37; *47;*49;*52;*54;*57;*65;*72), *11, *12, *14A, *14B, *15, *17, *18, *19, *20, *21A, *21B, *30, *40, *41, *42, *44, *56A, *56B, *58, *64, *69 |
Agena Bioscience |
| GenoChip Tamox |
*3, *4, *5, *6, *7, *8, *9, *10, *11, *17, *29, *41, *xN |
Akabiotech |
| INFINITI CYP450 2D6I |
*2, *2A *3, *4, *5, *6, *7, *8, *9, *10, *12, *14, *17, *29, *41, *xN |
AutoGenomics |
| VeraCode ADME Core Panel |
*2A, *3, *4, *5, *6, *7, *8, *9, *10, *11, *12, *14, *15, *17, *18, *19, *20, *21, *38, *41, *42, *44, *56 |
Illumina |
| GenoChip CYP2D6 | *3, *4, *5, *6, *7, *8, *9, *10, *11, *17, *29, *41, *xN | PharmGenomics |
†The xTAG CYP2D6 Kit v3 assay is the only CYP2D6 platform approved by the US FDA for in vitro diagnostic testing.
‡The Ion AmpliSeq Pharmacogenomics Research Panel is the only commercial sequencing assay presented in the table.