Table 2.

Summary of planned data extraction from full-text articles selected for inclusion in the scoping review

Study characteristics	Extracted data
General information	• Authors, country of origin, title, year of publication
Study design	• Systematic review/meta-analysis, interventional (RCT), observational (cohort, case-control, cross sectional/survey) • For longitudinal studies, the beginning and end year of the study
Study type	• Descriptive and/or analytical
Population characteristics	• Selection criteria (inclusion/exclusion) • Adult, pediatric • Waitlisted transplant candidates, transplant recipients and/or donors
Sample size	• Number of participants (overall, by sex/gender)
Type of organ under study	• Stem cells, tissues, and/or solid organs
Exposure, outcome, and covariates	• Exposure: health risk factors/predictors • The main health outcome under study (e.g., patient/graft survival, pharmacokinetics/pharmacodynamics, health services access, utilization, interaction with the healthcare system, cost) • Covariates  ° Sex related covariates: anatomy (reproductive organ, proportion of fat and muscle), biological variables (hormones, genetic profile, gene expression), physiological variables (blood and serologic parameters)  ° Gender-related covariates: gender roles (housework, child care), gender identity (personality traits), gender relationships (social support), institutionalized gender (education level, profession, personal income), behavioral and cultural variables (smoking, drinking, occupation
Research theme	• Biomedical, clinical, health system/services, population health
Sex and gender consideration
Appropriate application of definitions	• Yes • No (Sex and gender used interchangeably and erroneously)
Inclusion in the primary research question/objective/hypothesis	• Yes • No
Consideration in study design	• Are both sexes considered? (y/n) • Were only men or women included? (y/n) • Was an explanation for sex/gender exclusion/inclusion provided (e.g., not necessary, not feasible)? (y/n)
Consideration in analysis	• How was sex considered in the analyses?  ° Descriptive (Table 1)  ° Primary exposure (effect size)  ° Confounder (included in multivariable models, restriction (sensitivity and/or subgroup analyses) or effect measure modifier (included in interaction terms followed by stratification of the main effect by sex if the interaction term is statistically significant) • How was gender considered in the analyses?  ° Gender was accounted for by considering sex-related associations  ° Gender story was sought by applying second-level disaggregation by sex  ° Gender story was sought by using gender-related variables  ° Gender index/score was created to analyze gender independently of sex   ▪ Summing up different variables to create a score   ▪ Regression variables to predict male/female sex   ▪ Factor analysis to capture underlying gender-based constructs   ▪ Create a ranking based on the male/female distribution to a single variable
Consideration in study results reporting	• Were analyses by sex and/or gender clearly presented in the results section, tables, and/or figures?  ° Levels of sex and gender integration:   ▪ Gender unequal   ▪ Gender blind   ▪ Gender sensitive   ▪ Gender specific   ▪ Gender transformative
Consideration in the discussion, conclusion, and/or recommendations	• Statements, limitations pertinent to sex and gender research