Table 4.
Predictive values of the NAC response assessment based on changes from baseline (p values) and CRI (sensitivity and specificity) from [HbT], SO2, [Hb], and [HbO2] measurements at the tumor ROI for each time bin.
| % Therapy Complete | % Change from Baseline | Cumulative Response Index (CRI) | ||||||
|---|---|---|---|---|---|---|---|---|
| [HbT] | SO2 | [Hb] | [HbO2] | [HbT] | SO2 | [Hb] | [HbO2] | |
| p value | p value | p value | p value | Sens/Spec | Sens/Spec | Sens/Spec | Sens/Spec | |
| 10 (0, 20] | 0.9 | 0.8 | 0.6 | 1 | 0.33/1 | 0.5/0.5 | 0.33/0.5 | 0.5/0.5 |
| 30 (20, 40] | 0.06 | 0.06 | 0.2 | 0.06 | 0.67/0.5 | 0.83/1 | 0.67/0.5 | 0.83/1 |
| 50 (40, 60] | 0.01 | 0.01 | 0.46 | 0.01 | 0.83/1 | 1/1 | 0.67/0 | 0.83/1 |
| 70 (60, 80] | 0.05 | 0.002 | 0.6 | 0.02 | 0.83/1 | 1/1 | 0.67/0.5 | 1/1 |
| 90 (80, 100] | 0.01 | 0.01 | 0.14 | 0.004 | 1/0.5 | 1/1 | 0.5/0.5 | 1/1 |