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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Adv Drug Deliv Rev. 2017 Jun 15;115:3–22. doi: 10.1016/j.addr.2017.06.003

Figure 4. Metformin related drug carriers for gene delivery.

Figure 4

A. Chemical structure of PolyMet as both a drug and a gene carrier. B. Schematic illustration of PolyMet NPs. Anionic HA and siRNA were condensed by cationic PolyMet into a negatively charged PolyMet/(HA.siRNA) complex. The complex was further coated with DOTAP/cholesterol cationic liposomes. DSPE-PEG and DSPE-PEG-anisamide (AA) were post-inserted onto the particles to form the LPH-PolyMet NPs. C. Chemical structures of DOTAP, metformin and DOBP. D. Schematic illustration of LPD-TRAIL NPs using metformin-lipid as a carrier for gene delivery. Copyright of 2016 Nature group [71] and Elsevier [140].