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. 2017 Sep 5;9:280. doi: 10.3389/fnagi.2017.00280

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Copyright © 2017 McGuiness, Scheinert, Asokan, Stadler, Lee, Rani, Kumar, Foster and Ormerod.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Indomethacin improved difference scores in middle-aged rats. Mean (± S.E.M.) differences in % Time spent in the target quadrant on the 2nd vs. 1st session are shown for rats treated with vehicle (white), rosiglitazone (gray), or indomethacin (black). Middle-aged indomethacin-treated rats exhibited bigger improvements in the % time spent in the target quadrant across sessions than middle-aged vehicle-treated rats (^*p < 0.05). Although, rosiglitazone-treated aged rats (p < 0.05) and indomethacin-treated middle-aged and aged rats (p < 0.01) exhibited higher difference scores than young rats within each drug group, the unexpectedly poor delayed probe trial performances exhibited by young rats made interpretation of the effects of age within drug treatment difficult.