Table 2.
Population characteristics
| exposed in vivo | exposed ex vivo | ||||
|---|---|---|---|---|---|
| Parameter | HV | sCAD | HV | sCAD | aCAD |
| (n = 24) | (n = 24) | (n = 35) | (n = 35) | (n = 35) | |
| Age (year) | 26.2 (8.6) | 62.8 (7.0) | 24.6 (7.5) | 64.0 (7.8) | 64.4 (12.9) |
| Height (cm) | 175 (8.7) | 177 (6.7) | 176 (8.7) | 177 (6.3) | 176 (10.7) |
| Body weight (kg) | 70.0 (11.3) | 85.0 (12.8) | 69.8 (10.8) | 86.5 (13.3) | 81.4 (19.2) |
| BMI (kg/m2) | 22.5 (1.8) | 27.0 (3.3) | 22.3 (1.9) | 27.4 (3.3) | 26.1 (5.3) |
| Gender | |||||
| Female (n) | 14 (58%) | 1 (4%) | 18 (51%) | 1 (3%) | 11 (31%) |
| Male (n) | 10 (42%) | 23 (96%) | 17 (49%) | 34 (97%) | 24 (69%) |
| Revascularisation | procedure | ||||
| CABG (n) | 12 (50%) | 14 (40%) | |||
| PCI (n) | 12 (50%) | 21 (60%) | 35 (100%) | ||
| Coronary involved | |||||
| Cx (n) | 6 (25%) | 10 (29%) | 15 (43%) | ||
| LAD (n) | 7 (29%) | 8 (23%) | 19 (54%) | ||
| RCA (n) | 6 (25%) | 12 (34%) | 15 (43%) | ||
| Unknown (n) | 10 (42%) | 13 (37%) | 12 (34%) | ||
Characteristics as mean (standard deviation) or number (percentage) of different populations, who were exposed in vivo to MDCO-216 or who were exposed ex vivo to both MDCO-216 and ETC-216. aCAD Patients with acute coronary artery disease (CAD); BMI Body mass index; CABG Coronary artery bypass grafting; Cx Circumflex artery; HV Healthy volunteers; LAD Left anterior descending artery; PCI Percutaneous coronary intervention; RCA Right coronary artery; sCAD Patients with stable coronary artery disease (CAD).