Fig. 3.

Visual predictive checks for CdA and CAde in urine of intravenously and orally administered CdA. Light blue shaded area indicates simulated median with uncertainty; pink shaded area indicates simulated 5th and 95th percentiles with uncertainty; solid blue line indicates observed median; dashed blue line indicates observed 5th and 95th percentiles. a Based on 83 samples from 16 subjects; b based on 83 samples from 16 subjects; c based on 40 samples from 16 subjects; d based on 49 samples from 16 subjects. CdA cladribine, CAde 2-chloroadenine, IV intravenous