Fig. 4.

Visual predictive checks for CdA in plasma after oral administration of CdA in a fasted and fed conditions, and b with and without IFNβ-1a coadministration. Light blue shaded area indicates simulated median with uncertainty; pink shaded area indicates simulated 5th and 95th percentiles with uncertainty; solid blue line indicates observed median; dashed blue line indicates observed 5th and 95th percentiles. (1) Based on 417 samples from 16 subjects; (2) based on 210 samples from 16 subjects; (3) based on 210 samples from 16 subjects; (4) based on 209 samples from 16 subjects. CdA cladribine, IFN interferon