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. 2017 Feb 22;56(10):1231–1244. doi: 10.1007/s40262-017-0515-7

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Visual predictive check plots of the five CYP probe drugs after oral [left panel (1)] and intravenous [right panel (2)] administration: a caffeine (CYP1A2); b metoprolol (CYP2D6); c midazolam (CYP3A4); d omeprazole (CYP2C19); e S-warfarin (CYP2C9). The closed circles represent the observed data points after 36 h of fasting and the open circles represent the control observations. The solid (36 h fasting) and dashed (control) lines represent the 10th and 90th percentiles of the simulated data. CYP cytochrome P450, conc concentration