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Effect of fasting on post hoc individual clearance rates of the five CYP probe drugs after oral (left panel) and intravenous (right panel) administration of the cocktail: a caffeine (CYP1A2); b metoprolol (CYP2D6); c midazolam (CYP3A4); d omeprazole (CYP2C19); e S-warfarin (CYP2C9). The closed circles represent the median values. CYP cytochrome P450, po oral, iv intravenous
