Table 1.
Baseline characteristics
| Patient characteristics | Median (range) |
|---|---|
| Age, years | 23 (19–33) |
| Height, cm | 186 (175–194) |
| Body weight, kg | 80 (68–103) |
| Ethnicity [n = 12] | Caucasian |
| Genotype [n = 9] | n (%) |
|---|---|
| CYP1A2 | |
| *1A/*1F (EM) | 5 (56) |
| *1F/*1F (EM) | 4 (44) |
| CYP2C9 | |
| *1/*1 (EM) | 1 (11) |
| *1/*2 (IM) | 5 (56) |
| *1/*3 (IM) | 3 (33) |
| CYP2C19 | |
| *1/*1 (EM) | 2 (22) |
| *1/*2 (IM) | 4 (44) |
| *1/*4 (IM) | 1 (11) |
| *1/*8 (IM) | 1 (11) |
| *1/*17 (EM) | 1 (11) |
| CYP2D6 | |
| *1/*1 (EM) | 1 (11) |
| *1/*1 (xN) (UM) | 1 (11) |
| *1/*2 (EM) | 1 (11) |
| *1/*3 (IM) | 1 (11) |
| *1/*4 (IM) | 4 (44) |
| *4/*4 (PM) | 1 (11) |
| CYP3A4 | |
| *1A/*1A (EM) | 9 (100) |
EM extensive metabolizer, IM intermediate metabolizer, PM poor metabolizer, UM ultra-rapid metabolizer, xN allele duplication