| Short-term fasting influences systemic drug metabolism mediated by cytochrome P450 (CYP) 1A2, CYP2C9 and CYP2D6 but did not affect oral bioavailability. |
| The effect of fasting is enzyme specific since short-term fasting affected systemic clearance in a non-uniform pattern. |
| Additional research is warranted to determine if dose adjustments of drugs metabolized by CYP are necessary to improve drug treatment in patients with fasting-related consequences, such as malnutrition, or in combination with diets based on therapeutic fasting. |
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