Table 1.
Characteristics of cases with Alzheimer’s disease and matched controls.
| Cases with Alzheimer’s disease N = 173 |
Matched controls N = 684 |
||||
|---|---|---|---|---|---|
| Variable | n | (%) | n | (%) | P-value∗ |
| Age group (years) | 0.99 | ||||
| 65–74 | 32 | (18.5) | 128 | (18.7) | |
| 75–84 | 110 | (63.6) | 436 | (63.7) | |
| ≥85 | 31 | (17.9 | 120 | (17.5) | |
| Age (years), mean (standard deviation)† | 80.2 | (5.61) | 80.0 | (5.69) | 0.19 |
| Duration of exposure to tamoxifen (years), mean (standard deviation)† | 2.55 | (2.00) | 2.28 | (1.80) | 0.15 |
| Ever use of tamoxifen | 134 | (77.5) | 360 | (52.6) | <0.001 |
| Ever use of aromatase inhibitors | 30 | (17.3) | 88 | (12.9) | 0.13 |
| Comorbidities | |||||
| Alcohol-related disease | 1 | (0.58) | 3 | (0.44) | 0.81 |
| Cerebrovascular disease | 24 | (13.9) | 89 | (13.0) | 0.76 |
| Chronic kidney disease | 12 | (6.94) | 45 | (6.58) | 0.87 |
| Chronic obstructive pulmonary disease | 48 | (27.8) | 189 | (27.6) | 0.98 |
| Diabetes mellitus | 66 | (38.2) | 260 | (38.0) | 0.97 |
| Hyperlipidemia | 78 | (45.1) | 305 | (44.6) | 0.91 |
| Hypertension | 143 | (82.7) | 564 | (82.5) | 0.95 |
Data are presented as the number of subjects in each group, with percentages given in parentheses, or mean with standard deviation given in parentheses. ∗Chi-square test, and †t-test comparing cases with Alzheimer’s disease and matched controls.