Table 2.

Adjusted associations of health outcomes with substantial pain.^a

		Number (%) or mean (SD)	Adjusted odds ratio (95% confidence interval)
Depression screen	Negative	1,790 (80.8)	Reference
	Positive	425 (19.2)	4.03 (3.17, 5.14)
Significant fatigue	Negative	733 (34.5)	Reference
	Positive	1,395 (65.6)	6.74 (4.89, 9.31)
Anxiety	No	1,676 (71.0)	Reference
	Yes	684 (29.0)	2.36 (1.91, 2.92)
Mental health QOL	N = 2,272	66.6 (65.7–67.5)	−14.7 (−16.6 to −12.8)

^aAdjusted for age, gender, duration of MS and level of disability. QOL, quality of life.