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. 2017 Sep 5;11:494. doi: 10.3389/fnins.2017.00494

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Copyright © 2017 Nuzzi and Tridico.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram showing perspectives of mesenchymal stem cells for glaucoma. Autologous mesenchymal stem cells can be extracted from different sources (such as bone marrow and adipose tissue) and can be used to replace retinal cell elements, lost due to glaucomatous injury, since they are able to migrate toward the optic nerve head and the retinal ganglion cell layer (even after intravitreal injection). MSCs can also produce neurotrophic factors providing neuroprotection and reactivation of quiescent cells in the retina.