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. 2017 Sep 5;8:611. doi: 10.3389/fphar.2017.00611

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Copyright © 2017 Zhang, Wang, Ying, Jin, Luo, Xu, Xu, Dong, Xiao, Tong and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Yougui pills could not inhibit cartilage degradation in TGF-βRII^Col2ER mice. (A) Histological knee joint sections (50×) stained using Alcian Blue Hematoxylin/Orange G and Toluidine Blue. Joint degenerations are labeled (black arrows: cartilage degradation, blue arrows: osteophyte formation, yellow arrows: subchondral sclerosis). Cartilage architecture was evaluated using the Osteomeasure System to detemine the tibial cartilage area (B) and tibial cartilage thickness (C) OARSI scoring of the sections analyzed by histomorphometry was also performed (D) Bars represent Mean ± SD (n = 10). ^∗P < 0.001.