FIGURE 1.

Wild-type GD-SH-01 induces significantly greater apoptosis than attenuated HEP-Flury. (A) Schematic representations of the gene order of GD-SH-01, HEP-Flury, and rRABVs. (B) NA cells were infected with GD-SH-01, HEP-Flury, or chimeric viruses. Cells in early stage apoptosis are Annexin V⁺/PI^-, while dead cells correspond to those marked Annexin V⁺. (C) Chart plot of host cell apoptosis at 2 dpi. (D) Percentages of TUNEL-positive cells at 2 dpi. Data are represented as means ± SD of three independent experiments. One-way ANOVA followed by Bonferroni’s multiple comparison test. Comparing with HEP-Flury, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, and ns, not significant.