FIGURE 6.

Viral RNA synthesis but not viral replication is required for the induction of host cell apoptosis by GD-SH-01 and rHEP-shP. NA cells were infected with GD-SH-01, HEP-Flury, rHEP-shP, or rGDSH-P. (A) Viral growth kinetics of the four RABVs. (B) Copy numbers of intracellular viral gRNA. (C) Copy numbers of intracellular viral mRNA. Data are represented as means ± SD of three independent experiments. One-way ANOVA followed by Bonferroni’s multiple comparison test. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, and ns, not significant.