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. 2017 Sep 5;8:598. doi: 10.3389/fphar.2017.00598

FIGURE 2.

FIGURE 2

Effect of acute administration of AEAPR (A) and AEAPR (B) on CFA-induced paw edema. Animals (six mice each group) were treated orally with vehicle (distilled water), indomethacin (Indo), MEAPR or AEAPR (125, 250, and 500 mg/kg), 24 h after intraplantar injection of Complete Freund’s adjuvant (CFA: 20 μl). Each point represents the mean ± SEM of the paw thickness (in mm), before (basal level: BL), 24 h after the injection of CFA (time point 24 h) and at the time points indicated after drug administration. Holm–Sidak post hoc analysis; ap < 0.05, bp < 0.01 and cp < 0.001 in comparison with CFA + vehicle treated group; dp < 0.05; ep < 0.01 in comparison with CFA + indomethacin treated group, using Holm–Sidak post hoc analysis.