FIGURE 3.

Effect of acute administration of AEAPR (A) and MEAPR (B) on mechanical hypersensitivity in mice. Animals (six mice each group) were treated orally with vehicle (distilled water), indomethacin (Indo), MEAPR or AEAPR (125, 250, and 500 mg/kg), 24 h after intraplantar injection of Complete Freund’s adjuvant (CFA; 20 μl). Each point represents the mean ± SEM of the paw withdrawal threshold (in grams) to hind paw stimulation, before (basal level: BL), 24 h after the injection of CFA (time 24 h) and at the times indicated after drug administration. ^ap < 0.05, ^bp < 0.01 and ^cp < 0.001 in comparison with CFA + vehicle treated group; ^dp < 0.05; ^ep < 0.01 and ^fp < 0.001 in comparison with CFA + indomethacin treated group, using Holm–Sidak post hoc analysis.