FIGURE 6.

Effect of single administration of AEAPR (A) and MEAPR (B) in the hot plate test. Animals (six mice each group) were treated orally with vehicle (distilled water), indomethacin (Indo), MEAPR or AEAPR (125, 250, 500 mg/kg or 500 mg/kg + naloxone (1 mg/kg) (Nal), prior to 55°C thermal tests. Naloxone was administered alone or 30 min before administration of AEAPR and MEAPR. Each point represents the mean ± SEM of the response latency (in seconds) at different time points after the drug administration. ^ap < 0.05, ^bp < 0.01, and ^cp < 0.001 in comparison with the vehicle-treated group; ^dp < 0.05, ^ep < 0.01, and ^fp < 0.001 in comparison with the indomethacin-treated group, using Holm–Sidak post hoc analysis.