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. 2017 Sep 5;8:598. doi: 10.3389/fphar.2017.00598

FIGURE 7.

FIGURE 7

Effect of MEAPR and AEAPR on the paw licking response induced by formalin in mice. Animals were treated orally with vehicle (distilled water), indomethacin (Indo), MEAPR or AEAPR (125, 250, 500 mg/kg or 500 mg/kg + naloxone, prior to intraplantar injection of formalin (20 μl). Naloxone was administered alone or 30 min before administration of AEAPR and MEAPR. The total time spent licking the hind paw was measured (A) in the first phase (0–5 min) and (B) in the second phase (15–30 min) after intraplantar injection of formalin. Vertical bars represent mean ± SEM of licking time for six mice in each group. The symbols denote the significance levels (one-way ANOVA followed by Newman–Keuls test): ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 compared with the vehicle-treated group; # p < 0.05 compared with the indomethacin-treated group. AEAPR, aqueous extract of Anacyclus pyrethrum root; MEAPR, methanol extract of Anacyclus pyrethrum root; Indo, indomethacin; Nal, naloxone.