Table 2.
Inter-group comparison for men.
| Arterial hypertension group (AHG) n = 76 | Cushing’s disease (CD) n = 8 | Healthy volunteers (HV) n = 24 | p-Value | Post hoc tests | |
|---|---|---|---|---|---|
| Age (years), mean ± SD | 45.3 ± 9.3 | 45.0 ± 13.4 | 41.8 ± 7.7 | 0.276 | – |
| HR (bpm), mean ± SD | 68.7 ± 9.0 | 71.3 ± 10.5 | 65.3 ± 11.4 | 0.223 | – |
| Systolic blood pressure (mmHg), mean ± SD | 121.6 ± 9.6 | 132.1 ± 12.9 | 116.6 ± 9.4 | 0.0007 | AHG vs CD* |
| HV vs CD# | |||||
| Diastolic blood pressure (mmHg), mean ± SD | 78.3 ± 7.3 | 84.3 ± 10.1 | 73.3 ± 8.0 | 0.001 | AHG vs HV* |
| HV vs CD** | |||||
| Body mass index (kg/m2), mean ± SD | 29.1 ± 3.6 | 34.1 ± 8.1 | 26.2 ± 2.4 | <0.00001 | AHGvs HV** |
| AHG vs CD** | |||||
| HV vs CD# | |||||
| Echocardiography | |||||
| LVH, n (%) | 8 (10.5) | 3 (37.5) | 3 (12.5) | 0.055 | – |
| LVDD, n (%) | 11 (14.5) | 4 (50.0) | 0 (0.0) | 0.008 | – |
| LVEDD (mm), mean ± SD | 49.5 ± 3.1 | 48.6 ± 2.9 | 49.8 ± 3.8 | 0.685 | – |
| RVEDD (mm), mean ± SD | 31.4 ± 2.8 | 33.4 ± 2.2 | 30.0 ± 3.0 | 0.016 | HV vs CD* |
| LA (mm), mean ± SD | 38.6 ± 2.6 | 38.3 ± 3.3 | 36.8 ± 3.2 | 0.0004 | AHG vs HV* |
| Left ventricular mass index (g/m2), mean ± SD | 91.8 ± 16.5 | 111.8 ± 20.2 | 89.0 ± 20.9 | 0.012 | AHG vs CD* |
| HV vs CD* | |||||
| LVEF (%), mean ± SD | 66.1 ± 3.5 | 66.6 ± 3.6 | 67.3 ± 3.3 | 0.328 | – |
| GLS (%), mean ± SD | −18.8 ± 2.2 | −17.2 ± 2.1 | −19.6 ± 2.2 | 0.001 | AHG vs CD** |
| HV vs CD** | |||||
| E/A (–), mean ± SD | 1.18 ± 0.35 | 0.84 ± 0.20 | 1.30 ± 0.35 | 0.008 | AHG vs CD* |
| HV vs CD** | |||||
| E′ (cm/s), mean ± SD | 10.5 ± 2.7 | 8.3 ± 2.9 | 12.6 ± 2.4 | 0.0002 | AHG vs HV** |
| HV vs CD# | |||||
| E/e′, mean ± SD | 6.6 ± 1.6 | 7.4 ± 1.9 | 5.9 ± 1.1 | 0.0495 | HV vs CD* |
*p < 0.05; **p < 0.01; #p < 0.001.
E/A, mitral flow early (E) and late (A) phase ratio; E/e′, mitral flow early (E) phase and mitral septal annulus early diastolic velocity (e′) ratio; GLS, global longitudinal strain; LA, left atrium diameter; LVDD, left ventricular diastolic dysfunction; LVEDD, left ventricular end diastolic diameter; LVEF, left ventricular ejection fraction; LVH, left ventricular hypertrophy; RVEDD, right ventricular end diastolic diameter.