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Aβ oligomers inhibit the PI3K/Akt pathway and activate the ERK pathway in SH-SY5Y cells. SH-SY5Y cells were treated with 1 μM Aβ oligomer for various durations as indicated. Western blotting analysis was used to determine the expression of (a) pSer473-Akt, (b) pSer9-GSK3β, and (c) pERK. Data were the mean ± SEM of three separate experiments; ∗p < 0.05 and ∗∗p < 0.01 versus the control group (ANOVA and Tukey's test).
