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. 2017 Aug 8;2017:6792543. doi: 10.1155/2017/6792543

Figure 8.

Figure 8

LY294002 and wortmannin significantly abolished the neuroprotective effects of fucoxanthin against Aβ oligomer-induced neuronal loss in SH-SY5Y cells. SH-SY5Y cells were treated with 10 μM LY294002 (LY) or 0.05 μM wortmannin (Wort). After 0.5 h, 3 μM fucoxanthin was added. Aβ oligomers (1 μM) were added at 2 h after the addition of fucoxanthin. The MTT assay was used to measure cell viability at 24 h after the treatment of Aβ oligomers. Data, expressed as percentage of control, were the mean ± SEM of three separate experiments; ##p < 0.01 versus the control group, ∗∗p < 0.01 versus the Aβ oligomer group, and $p < 0.05 and $$p < 0.01 versus the fucoxanthin plus Aβ oligomer group (ANOVA and Tukey's test).