Effect of acute systemic administration of LY2444296 (0, 3 mg/kg i.p.) on U69,593 (0, 0.32 mg/kg s.c.)-mediated A) conditioned place aversion (n= 6/group), B) mean locomotor activity over 4 conditioning days (n= 6/group). Panel C shows the effect of acute systemic administration of LY2444296 (0, 1, 3 mg/kg i.p.) on U69,593 (0, 0.32 mg/kg s.c.)-increased serum corticosterone (n= 8–10/group). All panels show the Mean ±SEM. *** p<0.001, ** p<0.01, * p<0.05 versus vehicle/vehicle group; ### p<0.001, ## p<0.01, # p<0.05 versus LY2444296 vehicle/U69,593 0.32 mg/kg (SNK test).