Table 2.
Effect of the oral administration of Schinus terebinthifolius (St) bark extract on paw edema induced by histamine in Wistar rats.
| Groups | Dose (mg/kg) | Edema volume (mL) at different time interval | ||||
|---|---|---|---|---|---|---|
| 0.5 h | 1 h | 2 h | 3 h | 4 h | ||
| Control | — | 0.26 ± 0.02 | 0.62 ± 0.03 | 0.47 ± 0.02 | 0.44 ± 0.03 | 0.41 ± 0.03 |
| HXZ | 70 | 0.20 ± 0.01 | 0.27 ± 0.01 | 0.15 ± 0.02 | 0.10 ± 0.02 | 0.04 ± 0.01 |
| (23.1%) | (56.5%)∗ | (68.1%)∗ | (77.3%)∗ | (90,2%)∗ | ||
| St | 100 | 0.21 ± 0.02 | 0.41 ± 0.02 | 0.31 ± 0.02 | 0.24 ± 0.03 | 0.19 ± 0.04 |
| (19.2%) | (33.9%)∗ | (34.0%)∗ | (45.5%)∗ | (53.7%)∗ | ||
| St | 200 | 0.22 ± 0.02 | 0.32 ± 0.03 | 0.24 ± 0.03 | 0.18 ± 0.02 | 0.12 ± 0.02 |
| (15.4%) | (48.4%)∗ | (48.9%)∗ | (59.1%)∗ | (70.7%)∗ | ||
| St | 400 | 0.18 ± 0.03 | 0.28 ± 0.01 | 0.17 ± 0.02 | 0.06 ± 0.01 | 0.02 ± 0.01 |
| (30.8%) | (54.8%)∗ | (63.8%)∗ | (86.4%)∗ | (95.1%)∗ | ||
Values represent the mean ± SEM (n = 3/sex/group). HXZ: hydroxyzine. ∗Statistically different compared to the control. (One-way ANOVA followed by Tukey's multiple comparisons test, p < 0.05.)